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About Bioziny

BioZiny is a water based Nano Engineered Antibacterial Coating for Your Home. It is nano zinc oxide (ZnO) based, easy to apply, transparent, aqueous Coating for high touch surfaces at home, hospitals, medical centers, schools, busses, trains, airplanes, busses and other public places like shopping malls, Supermarkets, children’s play areas etc.
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BIOZINY & COVID-19

Can BIOZINY help contain COVID-19?

(Image Source: Pintrest)

To a very large extent YES[1]!

 

We must protect our surfaces because we have learnt that about 80% infectious diseases are transmitted by hands touching contaminated surfaces [2].

 

Hard nanoparticles with abrasive Surfaces, having sharp edges and corners at the nanometer scale,  dispersed uniformly in a thin polymer film on a metal, plastic or wooden surface, mechanically eliminate the Virus from surfaces by rupturing the capsid and exposing the RNA to Reactive Oxygen Species (ROS) genreated by ZnO Nanoparticles.

BIOZINY is a ZnO based Nano Engineered Antimicrobial Coating with particle size of ZnO varying from 20-50nm, dispersed uniformly in a polymer matrix.

 

Metal Oxides are geneally hard. Oxide Nanoparticles are abrasive on the surface at the nanometer level. They have sharp edges and corners of nanometer length.

 

These abrasive surfaces with sharp edges and corners act as a bed of thorns for the virus capsid.

 

Studies show that like all other viruses[3], the Novel Coronavirus is very fragile. The only thing that protects the virus is a thin outer layer or outer envelope called Capsid. This capsid protects the inner RNA, the blueprint of the virus, responsible for its replication.

 

The surface with abrasive nanoparticles act as a bed of nails for the virus and rupture the capsid when a virus or many viruses land on the surface[4].

 

The nanoparticles rupture the capsid exposing the RNA responsible for its replication.

 

The virus is thus eliminated.

 

Nano COVID-19

Further, as the size of ZnO NPs decrease beyond a certain number, Reactive Oxygen Species (ROS) are generated in ordinary light as ZnO is a semiconductor. Below a certain size of the nanoparticles, UV light is not needed for the generation of ROS.[Within the human body, ROS are deadly weapons used by phagocytes whenever a pathogen is detected. They are the natural defense of the human body against bacteria, viruses and other pathogens]

 

ROS generated by the nanoparticles of Zinc Oxide helps in deactivating the RNA that lies within the capsid or the virus as a whole.

 

For replication, a part of the virus will not be enough; a full virus would be required for hijacking a cell. Once the Capsid is ruptured and ROS generated damages the RNA, the risk of replication of one or many viruses is greatly reduced.

 

Thus there are chances that BIOZINY might be able to contain COVID-19 to a large extent.

 

There are varous scientific studies  where it has been  shown that ZnO Nanoparticles have the potential to be good Antiviral Agents [5-9]

References
[1] Yes, Hypothetically and as per scientific research papers. Currently there is no standard test to check Antivial Efficacy of a surface. A test for antiviral efficacy of a BIOZINY coated surface is pending.
[2] National Center for Preparedness, Detection, and Control of Infectious Diseases (NCPDCID) and National Center for Zoonotic, Vector-Borne, and Enteric Diseases (NCZVED), http://www.cdc.gov/CDCTV/HandsTogether/
[3] Adam Zlotnick et.al. Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids, https://elifesciences.org/articles/31473
[4]S. N. Zagrebel’nyi et.al. Interaction of Titaniun Dioxide Nanoparticles with Influenza Virus, Nanotechnologies in Russia, 2010, Vol. 5, Nos. 5–6, pp. 417–420
[5] Hadi Ghaffari et. al. Inhibition of H1N1 influenza virus infection by zinc oxide  nanoparticles: another emerging application of nanomedicine, Journal of Biomedical Science (2019) 26:70
[6] Lin Cai et. al. Preventing viral disease by ZnONPs through directly deactivating TMV and activating plant immunity in Nicotiana benthamiana, Environ. Sci.: Nano, 2019, 6, 3653
[7] Tejabhiram Yadavalli et.al. Role of Metal and Metal Oxide Nanoparticles as  Diagnostic and Therapeutic Tools for Highly Prevalent Viral Infections, Nanomedicine. 2017 January ; 13(1): 219–230.
[8] Lavanya Singh et.al. The role of nanotechnology in the treatment of viral infections , Ther Adv Infectious Dis 2017, Vol. 4(4) 105–131
[9] Kumar et.al. Virostatic potential of zinc oxide (ZnO) nanoparticles on capsid protein of cytoplasmic side of chikungunya virus, International Journal of Infectious Diseases 73S (2018) 3–398